;(21)– [PubMed]; Constantopoulos A, Karpathios T, Nicolaidou P, Maounis F, Matsaniotis N. Lazy-leukocyte syndrome. A case report . The lazy leukocyte syndrome was first described by Miller et al. in in two children with recurrent infection. They had normal humoral and cellular immunity . – LAZY LEUKOCYTE SYNDROME. LAZY LEUKOCYTE SYNDROME. Clinical Synopsis Toggle Dropdown. Inheritance. -? Autosomal dominant new.

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Looking For More References? A poor neutrophil response was obtained upon stimulation with both epinephrine and endotoxin, as well as upon induced inflammation by the Rebuck skin window technique.

Pathology of chemotaxis and random mobility. Single cases were reported by Costanopoulos et al.

Lazy leukocyte syndrome.

A bonus to all MIMmatch users is the option to sign up for updates on new gene-phenotype relationships. Transient ‘lazy-leukocyte’ syndrome during infancy.

Unfortunately, it is not free to produce. A characteristic abnormality of actin stndrome in neutrophils was demonstrated.


Relative to the genetics and the possibility that these cases represent new dominant mutations, parental age data would be of interest. The syndrome syndorme distinguished from neutrophil chemotactic deficiencies by the coexistence of defective random motility and peripheral blood neutropenia with normal bone marrow granulocyte reserve. We are determined to keep this website freely accessible. Bone marrow studies showed normal numbers of mature, morphologically normal neutrophils.

Clinical Synopsis Toggle Dropdown. Skin window mobilization test and chemotaxis were normal.

Leukocyte phagocytosis and bactericidal activity were normal. A severe neutropenia was found.

lazy leukocyte syndrome

Miller knew of 4 other cases. Both random mobility and chemotactic function were defective.

Expert curators review the literature and organize it to facilitate your work. None is familial and no parental consanguinity is known. OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine.


Lazy leukocyte syndrome.

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The year-old proposita had neutropenia and synrrome illness suggestive of persistent Epstein-Barr virus infection. Please consider making a donation now and again in the future. A new disorder of neutrophil function.

Autosomal dominant new mutations.

Mobilization of leukocytes after exercise was defective. The same abnormality probably leads to impaired deformability of neutrophils so that release of newly formed neutrophils from the bone marrow is reduced.