Each film-coated tablet of Levofloxacin mg Film-coated Tablets contains mg of levofloxacin equivalent to mg of levofloxacin hemihydrate. Name: Levofloxacin hemihydrate; Drug Entry: Levofloxacin. A synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling. Find patient medical information for Levofloxacin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.

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Patients with renal impairment Since levofloxacin is excreted mainly by the kidneys, the dose of levofloxacin should be adjusted in patients with renal levofloxaacin see section 4.

Therapeutics and clinical risk management. In patients treated with levofloxacin, determination of opiates in urine may give false-positive results.

Levofloxacin mg Film-coated Tablets – Summary of Product Characteristics (SmPC) – (eMC)

For the above-mentioned infections Levofloxacin mg Film-coated Tablets should hemihydratd used only when it is considered inappropriate to use antibacterial agents that are commonly recommended for the hejihydrate treatment of these infections. Frequencies are defined using the following convention: Photosensitisation has been reported with levofloxacin see section 4.

Musculoskeletal and connective tissue disorders. Unlike ciprofloxacin, levofloxacin does not appear to deactivate the drug metabolizing enzyme CYP1A2. Therefore, caution should be taken when using fluoroquinolones, including levofloxacin, in these populations.

Levofloxacin – Wikipedia

Pancytopenia Agranulocytosis Haemolytic anaemia. Phlebitis Hypotension Respiratory, thoracic and mediastinal disorders Dyspnoea Bronchospasm Pneumonitis allergic Gastro- intestinal disorders Diarrhoea Vomiting Nausea Abdominal pain Dyspepsia Flatulence Constipation Diarrhoea — haemorrhagic which in very rare cases may be indicative of enterocolitis, including pseudomembranous colitis see section 4. Expert Rev Anti Infect Ther.

Similarly, lung tissue concentrations range from two-fold to five-fold higher than plasma concentrations in the 24 hours after a single dose. Levofloxacin mg Film-coated Tablets tablets should be taken at least two hours before or after iron salts, zinc hemihdyrate, magnesium- or aluminium-containing antacids, or didanosine only didanosine formulations with aluminium or magnesium containing buffering agentsand sucralfate administration, since reduction of absorption can occur see section 4.


Hypoglycaemia particularly in diabetic patients see section 4.

Since levofloxacin is excreted mainly by the kidneys, the dose of levofloxacin should be adjusted in patients with renal impairment see section 4. Not Intended for Diagnostic or Therapeutic Use. Toxic epidermal necrolysis Stevens-Johnson syndrome Erythema multiforme Photosensitivity reaction see section 4. More research is needed to determine the best hemihydrats and length of treatment.

Psychotic reactions Psychotic reactions have been reported in patients receiving quinolones, including levofloxacin. As such, the intravenous and oral formulations of levofloxacin are considered interchangeable. Anaphylactic shock a Anaphylactoid shock a see section 4.

Elimination occurs mainly via excretion of unmetabolized drug in the urine. The bioavailability of Levofloxacin mg Film-coated Tablets is significantly reduced when administered together with sucralfate. Drugs in pregnancy and lactation: By continuing to browse the site you are agreeing to our policy on the use of cookies.

While its adverse effects are typically mild to moderate, serious reactions to levofloxacin sometimes occur. Vision disorders If vision becomes impaired or any effects on the eyes are experienced, an eye specialist should be consulted immediately see sections 4. The prevalence of resistance may vary geographically and with time for selected species and local information on resistance levofloxxacin desirable, levofooxacin when treating severe infections.

Both mechanisms amount to killing the bacterium.

Levofloxacin 500mg Film-coated Tablets

Jaundice and severe liver injury, including cases with fatal acute liver failure, primarily in patients with severe underlying diseases see section 4. Cases of hepatic necrosis up to fatal hepatic failure have been reported with levofloxacin, primarily in patients with severe underlying diseases, e.

Peripheral neuropathy Peripheral sensory neuropathy and peripheral sensory motor neuropathy have been reported in patients receiving fluoroquinolones, including levofloxacin, which can be rapid in its onset see section 4. The risk of tendinitis and tendon rupture is increased in patients aged over 60 years, in patients receiving daily doses of mg and in patients using corticosteroids.


Levofloxacin mg Film-coated Tablets may also be used to complete a course of therapy in patients who have shown improvement during initial treatment with intravenous levofloxacin; given the bioequivalence of the parenteral and oral forms, the same dosage can be used.

Similar results have been reported when levofloxacin is taken with iron supplements and multi-vitamins containing zinc. Low-level fluoroquinolone resistance ciprofloxacin MICs of 0. This can result in more action of drugs like warfarin, leading to more potential side effects, such as bleeding.

Santa Cruz Biotechnology, Inc. Fungal infection including Candida infection. Cross-resistance between levofloxacin and other fluoroquinolones is observed.

Patients should be advised to stop treatment and contact their doctor if signs and symptoms of hepatic disease develop such as anorexia, jaundice, dark urine, pruritus or tender abdomen. Approximately 16mm long and 8mm wide. Levofloxacin is a synthetic antibacterial agent of the fluoroquinolone class and is the S – lsvofloxacin of the racemic active substance ofloxacin. With decreasing renal function, renal elimination and clearance are decreased, and elimination half-lives increased as shown in the table below: The most common adverse reactions leading to discontinuation were gastrointestinal, including nausea, vomiting, and constipation.

Since sevofloxacin is the S-enantiomer, it binds more effectively to the DNA hemihydratw enzyme and topoisomerase IV than its counterpart enantiomer. Calcium salts have a minimal effect on the oral absorption of levofloxacin. Levofloxacin is also used as antibiotic eye drops to prevent bacterial infection. IUPAC name S fluoro-2,3-dihydromethyl 4-methylpiperazinyl oxo-7 H -pyrido[ 123 – de ]-1,4-benzoxazinecarboxylic acid.